ADRB1

Across TCGA pan-cancer cohorts, ADRB1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ADRB1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ADRB1 RNA is repressed in tumor relative to normal tissue. In most cancer types ADRB1 is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

KIRC, LUAD, and KIRP are the cancer types where ADRB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADRB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	II,III,IV	−1.340	<.001	12	view →
LUAD	Female	III,IV	−3.421	<.001	11	view →
KIRP	Female	All	−1.355	<.001	11	view →
COAD	All	IV	−1.018	<.001	10	view →
LUSC	Female	II,III,IV	−3.948	<.001	8	view →
BRCA	All	III,IV	−1.255	<.001	8	view →
HNSC	Male	All	−0.449	.008	8	view →
THCA	Male	III,IV	−0.614	<.001	6	view →
PRAD	All	All	+1.626	<.001	2	view →
KICH	All	II,III,IV	+1.170	.025	1	view →
READ	All	II,III,IV	−1.032	.020	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ADRB1–KIRC

Open the KIRC breakdown →