ADRA1A

Across TCGA cell cohorts, ADRA1A mutation is significantly associated with the RNA expression of many other genes, with 121 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADRA1A-associated genes across cancer lineages are USP29, PGK2, and IFNA13. Each is linked with ADRA1A in more than 1 cancer types. Because this analysis shows association rather than direction, both ADRA1A-to-partner and partner-to-ADRA1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, USP29 grouped by ADRA1A-low versus ADRA1A-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADRA1A→partner) and Y-score (partner→ADRA1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	USP29 →	+0.014	+3.523	<.001	.008	3	2
SOFT_TISSUE	PGK2 →	+0.209	+4.930	<.001	.008	3	1
SOFT_TISSUE	IFNA13 →	+0.072	+4.930	<.001	.008	3	1
LUNG_NSCLC_LUAD	PROP1 →	+0.028	+4.734	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR5H8 →	+0.017	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	OOSP4B →	+0.017	+5.266	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 121 associations by consensus.

USP29 by ADRA1A expression — LUNG_SCLC

Explore this box plot interactively →