ADNP

Across TCGA cell cohorts, ADNP mutation is significantly associated with the RNA expression of many other genes, with 605 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADNP-associated genes across cancer lineages are SKA1, HES3, and TGM7. Each is linked with ADNP in more than 1 cancer types. Because this analysis shows association rather than direction, both ADNP-to-partner and partner-to-ADNP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by ADNP-low versus ADNP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADNP→partner) and Y-score (partner→ADNP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SKA1 →	+0.818	+2.743	<.001	.001	3	2
CNS	HES3 →	+0.032	+4.321	<.001	.009	3	2
PANCREAS	TGM7 →	+0.006	+4.011	<.001	.009	3	1
URINARY_TRACT	C14orf180 →	+0.292	+4.087	.002	.009	3	1
URINARY_TRACT	CT45A6 →	+0.027	+4.087	<.001	.009	3	1
OESOPHAGUS	XAGE3 →	+0.163	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 605 associations by consensus.

SKA1 by ADNP expression — LARGE_INTESTINE

Explore this box plot interactively →