ADNP

Across TCGA pan-cancer cohorts, ADNP RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ADNP’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ADNP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ADNP is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

HNSC, BLCA, and COAD are the cancer types where ADNP tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADNP RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.826	<.001	11	view →
BLCA	Male	All	+0.710	<.001	11	view →
COAD	Male	All	+0.966	<.001	10	view →
LIHC	Female	II,III,IV	+1.154	<.001	9	view →
STAD	Male	II,III,IV	+1.135	<.001	8	view →
BRCA	All	III,IV	+0.761	<.001	8	view →
THCA	All	II,III,IV	−0.538	<.001	8	view →
LUSC	Male	II,III,IV	+0.773	<.001	6	view →
CHOL	Male	All	+2.495	<.001	5	view →
LUAD	All	All	+0.432	<.001	5	view →
READ	All	III,IV	+1.180	.005	4	view →
KIRP	All	IV	+0.892	.044	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ADNP–HNSC

Open the HNSC breakdown →