ADK

Across TCGA patient cohorts, ADK mutation is significantly associated with the RNA expression of many other genes, with 1,573 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADK-associated genes across cancer lineages are ANXA5, PDP2, and B3GNT8. Each is linked with ADK in more than 1 cancer types. Because this analysis shows association rather than direction, both ADK-to-partner and partner-to-ADK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ANXA5 grouped by ADK-low versus ADK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADK→partner) and Y-score (partner→ADK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ANXA5 →	+0.566	+3.098	<.001	<.001	3	2
UCEC	PDP2 →	+0.416	+2.479	.002	.001	3	2
UCEC	B3GNT8 →	-0.876	-3.584	.003	.002	3	2
UCEC	LINC02210 →	+0.356	+1.949	.009	.009	3	2
UCEC	NFKBIA →	-0.485	-3.406	.007	.005	3	2
COAD	MIR1179 →	+1.171	+7.741	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,573 associations by consensus.

ANXA5 by ADK expression — UCEC

Explore this box plot interactively →