ADK

Across TCGA pan-cancer cohorts, ADK RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ADK’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ADK RNA is repressed in tumor relative to normal tissue. In most cancer types ADK is over-expressed in tumor, although a few such as KIRC and LIHC show the opposite, repressed pattern.

KIRC, HNSC, and THCA are the cancer types where ADK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.982	<.001	12	view →
HNSC	All	III,IV	+0.668	<.001	12	view →
THCA	Female	II,III,IV	+0.749	<.001	10	view →
COAD	Female	II,III,IV	+1.037	<.001	9	view →
LIHC	Female	All	−0.881	<.001	9	view →
KICH	Female	All	−1.402	<.001	7	view →
UCEC	All	III,IV	+1.251	<.001	6	view →
BLCA	Male	All	+0.811	.010	6	view →
LUAD	All	All	+0.481	<.001	6	view →
READ	All	II,III,IV	+0.607	<.001	5	view →
STAD	All	II,III,IV	+0.571	.039	2	view →
KIRP	Male	All	−0.468	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ADK–KIRC

Open the KIRC breakdown →