ADK

Across TCGA pan-cancer cohorts, ADK RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated ADK data layer compared with 3 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ADK RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ADK expression acts as an unfavorable survival marker, although some lineages such as LGG and LIHC show a favorable association.

HNSC, UVM, and LUSC are the cancer types where ADK RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.600	0.717	<.001	178	view →
UVM	DFS	Median	III,IV	0.264	0.712	.003	65	view →
LUSC	OS	Quartile	III,IV	0.272	0.632	.001	59	view →
UCS	DFS	Median	III,IV	0.137	0.531	<.001	54	view →
LGG	OS	Median	All	0.868	0.748	<.001	37	view →
LIHC	OS	Quartile	II,III,IV	0.915	0.504	.001	32	view →
KIRC	DFS	Quartile	All	0.726	0.509	.001	31	view →
PAAD	DFS	Quartile	All	0.312	0.549	<.001	30	view →
LUAD	DFS	Tertile	IV	0.896	0.239	.006	21	view →
THCA	OS	Tertile	II,III,IV	0.986	0.888	.006	19	view →
MESO	OS	Tertile	All	0.429	0.697	.002	19	view →
BRCA	OS	Tertile	II,III,IV	0.483	0.669	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

ADK–HNSC (OS)

Open the HNSC breakdown →