Across TCGA patient cohorts, ADH1B mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADH1B-associated genes across cancer lineages are mTOR_pS2448, mTOR, and Annexin-1. Each is linked with ADH1B in more than 2 cancer types. Because this analysis shows association rather than direction, both ADH1B-to-partner and partner-to-ADH1B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADH1B→partner) and Y-score (partner→ADH1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.151	-2.302	.020	.034	3	3
SKCM	mTOR →	-0.253	-2.087	.001	.004	3	3
UCEC	Annexin-1 →	+0.551	+3.189	.016	.010	3	2
UCEC	Src_pY527 →	-0.580	-3.321	.002	.009	3	2
UCEC	VHL →	-1.047	-2.584	<.001	.010	3	2
SKCM	c-Met_pY1235 →	+0.064	+1.919	.019	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Exploration

ADH1B survival (RNA) · tumor vs normal (RNA) · all ADH1B data types