ADGRL2

Across TCGA patient cohorts, ADGRL2 mutation is significantly associated with the RNA expression of many other genes, with 7,361 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRL2-associated genes across cancer lineages are MRPS15, WDR74, and SAC3D1. Each is linked with ADGRL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADGRL2-to-partner and partner-to-ADGRL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS15 grouped by ADGRL2-low versus ADGRL2-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRL2→partner) and Y-score (partner→ADGRL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	MRPS15 →	+0.534	+3.700	<.001	.001	3	5
STAD	WDR74 →	+0.401	+2.618	.008	.005	3	5
STAD	SAC3D1 →	+0.618	+3.371	.002	.004	3	5
STAD	RCC1 →	+0.763	+3.471	<.001	.002	3	5
STAD	MRTO4 →	+0.499	+3.355	.002	.004	3	5
SKCM	CORO2B →	-1.011	-1.490	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,361 associations by consensus.

MRPS15 by ADGRL2 expression — STAD

Explore this box plot interactively →