ADGRL1

Across TCGA patient cohorts, ADGRL1 mutation is significantly associated with the total protein of many other genes, with 60 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRL1-associated genes across cancer lineages are eIF4E, PI3K-p85, and Caspase-7-cleavedD198. Each is linked with ADGRL1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADGRL1-to-partner and partner-to-ADGRL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ADGRL1-low versus ADGRL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRL1→partner) and Y-score (partner→ADGRL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.124	+1.691	.029	.011	3	4
STAD	PI3K-p85 →	+0.192	+3.000	.021	.034	2	4
UCEC	Caspase-7-cleavedD198 →	+0.590	+1.309	<.001	.013	3	3
STAD	Collagen-VI →	-0.337	-3.169	.012	.019	3	2
UCEC	Ku80 →	+0.222	+1.533	<.001	.004	3	2
UCEC	mTOR_pS2448 →	-0.125	-2.057	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 60 associations by consensus.

eIF4E by ADGRL1 expression — UCEC

Explore this box plot interactively →