ADGRL1

Across TCGA pan-cancer cohorts, ADGRL1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ADGRL1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ADGRL1 RNA is repressed in tumor relative to normal tissue. In most cancer types ADGRL1 is over-expressed in tumor, although a few such as KIRC and LUAD show the opposite, repressed pattern.

KIRC, COAD, and LIHC are the cancer types where ADGRL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADGRL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	−1.631	<.001	12	view →
COAD	All	II,III,IV	+0.542	<.001	9	view →
LIHC	Female	II,III,IV	+1.884	<.001	8	view →
HNSC	Male	All	+1.121	<.001	7	view →
LUSC	All	All	+0.585	<.001	5	view →
LUAD	Male	All	−0.686	<.001	4	view →
CHOL	All	All	+2.258	<.001	3	view →
BLCA	All	IV	−1.114	.004	3	view →
STAD	Male	II,III,IV	+1.028	.006	3	view →
READ	All	III,IV	+1.255	.017	2	view →
THCA	Male	II,III,IV	−0.548	.008	2	view →
PRAD	All	All	−0.303	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ADGRL1–KIRC

Open the KIRC breakdown →