ADGRL1

Across TCGA pan-cancer cohorts, ADGRL1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ADGRL1 data layer compared with 9 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ADGRL1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ADGRL1 expression acts as an unfavorable survival marker, although some lineages such as LGG and SCLC show a favorable association.

UVM, ACC, and LGG are the cancer types where ADGRL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.394	1.000	<.001	73	view →
ACC	OS	Tertile	All	0.420	0.872	<.001	51	view →
LGG	OS	Median	All	0.940	0.850	<.001	43	view →
SCLC	DFS	Quartile	II,III,IV	0.613	0.131	.001	34	view →
HNSC	DFS	Quartile	IV	0.777	0.576	.006	26	view →
PAAD	OS	Quartile	All	0.574	0.267	.001	22	view →
GBM	OS	Tertile	All	0.556	0.234	.001	18	view →
THYM	OS	Median	II,III,IV	0.974	0.622	.007	17	view →
STAD	DFS	Quartile	All	0.751	0.551	.010	14	view →
DLBC	OS	Median	All	1.000	0.482	.011	10	view →
UCEC	OS	Quartile	All	0.832	0.911	.019	10	view →
CHOL	OS	Tertile	III,IV	1.000	0.162	.024	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ADGRL1–UVM (OS)

Open the UVM breakdown →