ADGRL1

Across TCGA cell cohorts, ADGRL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,663 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ADGRL1-associated GO terms across cancer lineages are Subtelomeric heterochromatin formation, Epigenetic regulation of gene expression, and Nucleosome organization. Each is linked with ADGRL1 in more than 16 cancer types. Because this analysis shows association rather than direction, both ADGRL1-to-partner and partner-to-ADGRL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Subtelomeric heterochromatin formation grouped by ADGRL1-low versus ADGRL1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRL1→partner) and Y-score (partner→ADGRL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Subtelomeric heterochromatin formation →	+0.111	+1.019	.003	.009	3	17
BONE	Epigenetic regulation of gene expression →	+0.100	+2.044	<.001	<.001	3	15
BONE	Nucleosome organization →	+0.100	+1.665	<.001	<.001	3	15
BONE	Positive regulation of T-helper 17 cell lineage commitment →	+0.202	+2.058	<.001	<.001	3	14
BONE	Protein-DNA complex organization →	+0.073	+1.482	<.001	<.001	3	13
SOFT_TISSUE	Positive regulation of nuclear cell cycle DNA replication →	+0.139	+2.006	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,663 associations by consensus.

Subtelomeric heterochromatin formation by ADGRL1 expression — LUNG_SCLC

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