ADGRL1

Across TCGA cell cohorts, ADGRL1 mutation is significantly associated with the RNA expression of many other genes, with 1,454 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRL1-associated genes across cancer lineages are CCDC171, OR6C2, and MS4A12. Each is linked with ADGRL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRL1-to-partner and partner-to-ADGRL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC171 grouped by ADGRL1-low versus ADGRL1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRL1→partner) and Y-score (partner→ADGRL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCDC171 →	+0.307	+3.137	.006	.007	3	3
URINARY_TRACT	OR6C2 →	+0.178	+4.584	<.001	.002	3	2
LUNG_NSCLC_LUAD	MS4A12 →	+0.180	+4.212	<.001	.007	3	2
LARGE_INTESTINE	R3HCC1 →	+0.722	+2.743	.001	.001	3	2
LARGE_INTESTINE	APBA3 →	+0.614	+2.743	<.001	.001	3	2
LARGE_INTESTINE	RIC8B →	+0.589	+3.850	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,454 associations by consensus.

CCDC171 by ADGRL1 expression — LARGE_INTESTINE

Explore this box plot interactively →