ADGRF5

Across TCGA patient cohorts, ADGRF5 mutation is significantly associated with the RNA expression of many other genes, with 4,415 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRF5-associated genes across cancer lineages are NCKIPSD, CDT1, and RAD51. Each is linked with ADGRF5 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADGRF5-to-partner and partner-to-ADGRF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NCKIPSD grouped by ADGRF5-low versus ADGRF5-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRF5→partner) and Y-score (partner→ADGRF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	NCKIPSD →	+0.224	+1.548	.004	<.001	3	4
UCEC	CDT1 →	+0.816	+1.958	<.001	<.001	3	4
UCEC	RAD51 →	+0.687	+1.760	<.001	<.001	3	4
UCEC	RDH11 →	+0.349	+1.645	<.001	<.001	3	4
UCEC	RCC1 →	+0.329	+2.747	.003	<.001	3	4
UCEC	CDCA2 →	+0.691	+2.115	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,415 associations by consensus.

NCKIPSD by ADGRF5 expression — SKCM

Explore this box plot interactively →