ADGRE5

Across TCGA cell cohorts, ADGRE5 mutation is significantly associated with the mutation status of many other genes, with 6,296 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRE5-associated genes across cancer lineages are ABCA3, SCN1A, and PRR14L. Each is linked with ADGRE5 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADGRE5-to-partner and partner-to-ADGRE5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABCA3 grouped by ADGRE5-low versus ADGRE5-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRE5→partner) and Y-score (partner→ADGRE5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	ABCA3 →	+5.651	+5.651	<.001	<.001	1	5
CNS	SCN1A →	+6.044	+6.044	.001	.001	1	4
OVARY	PRR14L →	+4.562	+5.217	<.001	<.001	1	4
LUNG_NSCLC_LUAD	DOCK5 →	+4.772	+5.339	.004	.004	1	4
LUNG_NSCLC_LUAD	NCKAP5L →	+4.772	+5.339	.004	.004	1	4
BLOOD_Leukemia	THEMIS →	+4.794	+3.309	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,296 associations by consensus.

ABCA3 by ADGRE5 expression — SOFT_TISSUE

Explore this box plot interactively →