ADGRE5

Across TCGA pan-cancer cohorts, ADGRE5 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ADGRE5 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ADGRE5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ADGRE5 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

ACC, UVM, and SKCM are the cancer types where ADGRE5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.255	0.658	<.001	114	view →
UVM	OS	Median	All	0.361	0.783	<.001	103	view →
SKCM	OS	Median	All	0.416	0.241	<.001	66	view →
MESO	OS	Quartile	All	0.214	0.486	.002	66	view →
LIHC	OS	Median	All	0.458	0.690	<.001	57	view →
KIRC	DFS	Quartile	IV	0.801	0.238	<.001	54	view →
LGG	OS	Median	All	0.327	0.569	<.001	52	view →
KIRP	DFS	Median	All	0.790	0.921	<.001	36	view →
STAD	DFS	Tertile	II,III,IV	0.718	0.522	.007	35	view →
OV	OS	Tertile	III,IV	0.238	0.346	.007	34	view →
LAML	DFS	Median	All	0.353	0.567	<.001	34	view →
PAAD	OS	Median	All	0.413	0.568	.007	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ADGRE5–ACC (DFS)

Open the ACC breakdown →