ADGRB1

Across TCGA patient cohorts, ADGRB1 mutation is significantly associated with the RNA expression of many other genes, with 7,476 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRB1-associated genes across cancer lineages are THRAP3, CDKN3, and HNRNPR. Each is linked with ADGRB1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADGRB1-to-partner and partner-to-ADGRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, THRAP3 grouped by ADGRB1-low versus ADGRB1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRB1→partner) and Y-score (partner→ADGRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	THRAP3 →	+0.362	+1.671	.002	.007	3	5
UCEC	CDKN3 →	+0.712	+1.917	<.001	<.001	3	5
UCEC	HNRNPR →	+0.604	+2.091	<.001	<.001	3	5
UCEC	HIRIP3 →	+0.386	+4.003	<.001	<.001	3	4
COAD	SLC2A13 →	+0.558	+2.419	<.001	<.001	3	4
STAD	GUF1 →	+0.610	+3.338	.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,476 associations by consensus.

THRAP3 by ADGRB1 expression — UCEC

Explore this box plot interactively →