ADGRB1

Across TCGA pan-cancer cohorts, ADGRB1 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ADGRB1 data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ADGRB1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ADGRB1 expression acts as an unfavorable survival marker, although some lineages such as BRCA and ESCA show a favorable association.

UVM, KIRC, and BRCA are the cancer types where ADGRB1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.403	0.782	<.001	136	view →
KIRC	DFS	Median	All	0.530	0.721	<.001	116	view →
BRCA	OS	Median	III,IV	0.898	0.757	<.001	57	view →
THCA	OS	Median	II,III,IV	0.954	1.000	.001	50	view →
COAD	OS	Tertile	All	0.793	0.914	.001	41	view →
ACC	OS	Quartile	All	0.519	0.927	.004	30	view →
UCS	DFS	Median	IV	0.440	0.885	.015	30	view →
ESCA	OS	Median	III,IV	0.712	0.439	.008	24	view →
CHOL	OS	Tertile	All	0.852	0.129	.002	18	view →
CESC	DFS	Tertile	III,IV	0.461	0.777	.036	14	view →
UCEC	OS	Tertile	All	0.886	0.953	.007	14	view →
KIRP	DFS	Tertile	II,III,IV	0.119	0.665	.009	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ADGRB1–UVM (DFS)

Open the UVM breakdown →