ADGRB1

Across TCGA pan-cancer cohorts, ADGRB1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ADGRB1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ADGRB1 RNA is repressed in tumor relative to normal tissue. In most cancer types ADGRB1 is over-expressed in tumor, although a few such as COAD and UCEC show the opposite, repressed pattern.

COAD, UCEC, and BRCA are the cancer types where ADGRB1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADGRB1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.302	<.001	10	view →
UCEC	All	II,III,IV	−1.273	<.001	6	view →
BRCA	Female	All	−0.429	<.001	6	view →
KICH	Female	All	−0.913	<.001	5	view →
CHOL	All	All	+0.876	<.001	3	view →
LIHC	Female	All	+0.224	.004	3	view →
HNSC	Female	All	+0.575	.030	2	view →
LUAD	All	All	+0.383	.002	2	view →
PRAD	All	All	−0.317	<.001	2	view →
THCA	Male	III,IV	−0.308	.019	2	view →
LUSC	All	All	+0.318	.035	1	view →
STAD	All	All	−0.288	.036	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ADGRB1–COAD

Open the COAD breakdown →