ADGRB1

Across TCGA cell cohorts, ADGRB1 mutation is significantly associated with the RNA expression of many other genes, with 1,166 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRB1-associated genes across cancer lineages are PPIAL4F, PLA2G3, and MSH4. Each is linked with ADGRB1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRB1-to-partner and partner-to-ADGRB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4F grouped by ADGRB1-low versus ADGRB1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRB1→partner) and Y-score (partner→ADGRB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PPIAL4F →	+0.094	+4.930	<.001	.008	3	2
STOMACH	PLA2G3 →	+1.390	+3.263	.002	.005	3	2
STOMACH	MSH4 →	+0.190	+3.321	<.001	.003	3	2
LUNG_NSCLC_LUAD	R3HDML →	+0.098	+2.799	.001	.001	3	2
CNS	HTR1F →	+0.683	+3.584	<.001	.007	3	2
LARGE_INTESTINE	RPL3 →	+0.533	+2.652	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,166 associations by consensus.

PPIAL4F by ADGRB1 expression — SOFT_TISSUE

Explore this box plot interactively →