ADCY6

Across TCGA patient cohorts, ADCY6 protein abundance is significantly associated with the RNA expression of many other genes, with 2,648 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible ADCY6-associated genes across cancer lineages are RNF5, AGFG2, and DTX4. Each is linked with ADCY6 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADCY6-to-partner and partner-to-ADCY6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADCY6 versus RNF5 in HNSC, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY6→partner) and Y-score (partner→ADCY6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNF5 →	+1.012	+0.942	.006	.008	3	3
GBM	AGFG2 →	+0.637	+0.267	.001	.002	3	2
LUAD	DTX4 →	+0.763	+0.298	.001	<.001	3	2
LUAD	LRRC31 →	+1.476	+0.248	.003	.004	3	2
PDAC	CLU →	+0.995	+0.572	.004	<.001	2	3
LUAD	RNASE1 →	+0.815	+0.199	.003	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,648 associations by consensus.

ADCY6 vs RNF5 — HNSC

Explore this scatter interactively →