ADCY6

Across TCGA pan-cancer cohorts, ADCY6 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated ADCY6 data layer compared with 9 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher ADCY6 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ADCY6 expression acts as an unfavorable survival marker, although some lineages such as UVM and STAD show a favorable association.

CESC, UVM, and LIHC are the cancer types where ADCY6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.428	0.631	<.001	86	view →
UVM	DFS	Quartile	All	0.801	0.331	.001	82	view →
LIHC	DFS	Quartile	All	0.411	0.612	<.001	55	view →
LGG	DFS	Tertile	All	0.656	0.818	<.001	40	view →
STAD	OS	Median	All	0.735	0.587	.005	33	view →
LUAD	DFS	Tertile	IV	0.533	0.949	.003	24	view →
THCA	OS	Median	II,III,IV	0.932	1.000	.019	19	view →
SKCM	DFS	Median	III,IV	0.530	0.691	.010	18	view →
MESO	OS	Quartile	IV	0.191	0.889	.009	18	view →
ESCA	OS	Median	All	0.617	1.000	.009	15	view →
SCLC	DFS	Tertile	II,III,IV	0.976	0.308	.006	12	view →
BRCA	DFS	Quartile	III,IV	0.725	0.470	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

ADCY6–CESC (DFS)

Open the CESC breakdown →