ADCY4

Across TCGA patient cohorts, ADCY4 mutation is significantly associated with the RNA expression of many other genes, with 6,294 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCY4-associated genes across cancer lineages are FANCG, RNU6-1020P, and POLE2. Each is linked with ADCY4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADCY4-to-partner and partner-to-ADCY4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FANCG grouped by ADCY4-low versus ADCY4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY4→partner) and Y-score (partner→ADCY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FANCG →	+0.714	+2.653	<.001	<.001	3	4
LIHC	RNU6-1020P →	+0.385	+6.008	<.001	.002	3	3
UCEC	POLE2 →	+0.582	+1.828	<.001	<.001	3	3
UCEC	CINP →	+0.319	+1.860	<.001	<.001	3	3
SKCM	EMC9 →	+0.347	+2.166	.002	.008	3	3
UCEC	GLA →	+0.455	+3.223	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,294 associations by consensus.

FANCG by ADCY4 expression — UCEC

Explore this box plot interactively →