ADCY4

Across TCGA pan-cancer cohorts, ADCY4 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ADCY4 data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ADCY4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ADCY4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, KIRP, and UVM are the cancer types where ADCY4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.514	0.275	.001	89	view →
KIRP	DFS	Median	II,III,IV	0.256	0.681	<.001	82	view →
UVM	DFS	Tertile	All	0.383	0.726	<.001	64	view →
MESO	OS	Median	All	0.211	0.747	<.001	61	view →
COAD	DFS	Quartile	All	0.536	0.829	<.001	52	view →
UCEC	DFS	Median	II,III,IV	0.892	0.751	.001	46	view →
THYM	DFS	Tertile	II,III,IV	0.963	0.517	<.001	40	view →
SARC	DFS	Tertile	All	0.436	0.297	.011	25	view →
LGG	OS	Quartile	All	0.860	0.982	<.001	19	view →
LAML	DFS	Tertile	All	0.505	0.712	.011	18	view →
ESCA	DFS	Median	All	0.409	0.209	.001	14	view →
KIRC	DFS	Quartile	All	0.899	0.686	.002	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ADCY4–HNSC (OS)

Open the HNSC breakdown →