ADCY4

Across TCGA pan-cancer cohorts, ADCY4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ADCY4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ADCY4 RNA is repressed in tumor relative to normal tissue. In most cancer types ADCY4 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, LUAD, and KIRP are the cancer types where ADCY4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADCY4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	II,III,IV	−2.009	<.001	11	view →
LUAD	Male	All	−1.629	<.001	11	view →
KIRP	Male	All	−1.796	<.001	9	view →
LUSC	Female	All	−2.302	<.001	8	view →
BLCA	Male	III,IV	−1.355	<.001	8	view →
LIHC	All	II,III,IV	+0.622	<.001	8	view →
UCEC	All	All	−1.755	<.001	6	view →
BRCA	All	II,III,IV	−1.684	<.001	6	view →
COAD	All	IV	+0.597	.025	5	view →
CHOL	All	All	+1.397	.004	2	view →
THCA	All	IV	−0.765	.013	2	view →
KIRC	All	All	+0.382	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ADCY4–KICH

Open the KICH breakdown →