ADCY4

Across TCGA patient cohorts, ADCY4 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADCY4-associated genes across cancer lineages are A-Raf_pS299, p27_pT157, and 14-3-3_beta. Each is linked with ADCY4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCY4-to-partner and partner-to-ADCY4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A-Raf_pS299 grouped by ADCY4-low versus ADCY4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY4→partner) and Y-score (partner→ADCY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	A-Raf_pS299 →	-0.247	-2.991	.004	.036	3	2
COAD	p27_pT157 →	+0.263	+3.008	<.001	.019	3	2
UCEC	14-3-3_beta →	-0.095	-1.973	.002	.008	3	2
UCEC	eIF4E →	+0.192	+2.920	.003	<.001	3	2
UCEC	ACC1 →	+0.304	+1.201	.007	.028	3	2
UCEC	mTOR_pS2448 →	-0.101	-1.687	.029	.040	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

A-Raf_pS299 by ADCY4 expression — COAD

Explore this box plot interactively →