ADCY4

Across TCGA cell cohorts, ADCY4 mutation is significantly associated with the RNA expression of many other genes, with 57 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADCY4-associated genes across cancer lineages are KRT28, OR2L8, and GSG1L2. Each is linked with ADCY4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCY4-to-partner and partner-to-ADCY4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRT28 grouped by ADCY4-low versus ADCY4-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCY4→partner) and Y-score (partner→ADCY4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	KRT28 →	+0.044	+3.444	<.001	.003	3	2
LUNG_NSCLC_LUAD	OR2L8 →	+0.007	+3.681	<.001	.009	3	2
LARGE_INTESTINE	GSG1L2 →	+0.011	+3.700	<.001	.009	3	1
SKIN	AADACL4 →	+0.037	+4.054	.009	.004	3	1
BREAST	OR10K2 →	+0.047	+4.781	<.001	.003	3	1
BREAST	OR10T2 →	+0.137	+4.781	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 57 associations by consensus.

KRT28 by ADCY4 expression — OVARY

Explore this box plot interactively →