ADCK1

Across TCGA cell cohorts, ADCK1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADCK1-associated genes across cancer lineages are RS1, MPC1L, and PRSS58. Each is linked with ADCK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADCK1-to-partner and partner-to-ADCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RS1 grouped by ADCK1-low versus ADCK1-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADCK1→partner) and Y-score (partner→ADCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RS1 →	+0.006	+4.011	<.001	.009	3	1
PANCREAS	MPC1L →	+0.057	+4.786	<.001	.001	3	1
PANCREAS	PRSS58 →	+0.084	+5.584	<.001	<.001	3	1
BLOOD_Leukemia	SMIM31 →	+0.032	+4.276	<.001	.007	3	1
LARGE_INTESTINE	SCN11A →	+0.128	+3.772	.001	.007	3	1
LARGE_INTESTINE	C14orf180 →	+0.101	+3.155	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

RS1 by ADCK1 expression — PANCREAS

Explore this box plot interactively →