ADAMTS9

Across TCGA patient cohorts, ADAMTS9 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS9-associated genes across cancer lineages are Caspase-7-cleavedD198, FASN, and 4E-BP1. Each is linked with ADAMTS9 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAMTS9-to-partner and partner-to-ADAMTS9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ADAMTS9-low versus ADAMTS9-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS9→partner) and Y-score (partner→ADAMTS9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.980	+3.476	<.001	.002	3	4
STAD	FASN →	+0.526	+3.337	.002	.004	2	4
UCEC	4E-BP1 →	+0.318	+3.392	<.001	<.001	3	3
UCEC	eIF4E →	+0.158	+3.100	.005	<.001	3	3
UCEC	p27_pT198 →	+0.069	+1.152	.017	.048	3	3
COAD	HER3_pY1289 →	+0.089	+1.510	.009	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Caspase-7-cleavedD198 by ADAMTS9 expression — COAD

Explore this box plot interactively →