ADAMTS9

Across TCGA pan-cancer cohorts, ADAMTS9 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ADAMTS9’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ADAMTS9 RNA is repressed in tumor relative to normal tissue. In most cancer types ADAMTS9 is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH, THCA, and LIHC are the cancer types where ADAMTS9 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAMTS9 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	III,IV	−2.187	<.001	10	view →
THCA	Female	II,III,IV	+1.966	<.001	9	view →
LIHC	Female	II,III,IV	+1.294	<.001	9	view →
KIRP	All	II,III,IV	+1.015	.001	9	view →
COAD	Female	II,III,IV	+0.801	<.001	9	view →
BRCA	All	III,IV	−1.218	<.001	6	view →
LUSC	All	All	−1.162	<.001	5	view →
BLCA	All	All	−1.009	.009	5	view →
KIRC	Female	All	+0.911	<.001	5	view →
STAD	All	II,III,IV	+0.695	.014	4	view →
CHOL	All	All	+2.795	<.001	3	view →
READ	Male	All	+1.693	.004	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ADAMTS9–KICH

Open the KICH breakdown →