ADAMTS9

Across TCGA pan-cancer cohorts, ADAMTS9 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ADAMTS9 data layer compared with 14 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher ADAMTS9 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ADAMTS9 expression acts as an unfavorable survival marker, although some lineages such as THCA and HNSC show a favorable association.

UVM, ACC, and BLCA are the cancer types where ADAMTS9 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.402	0.727	<.001	122	view →
ACC	DFS	Median	All	0.523	0.791	<.001	66	view →
BLCA	OS	Quartile	IV	0.130	0.447	<.001	65	view →
THCA	DFS	Median	All	0.932	0.637	.002	58	view →
LIHC	DFS	Tertile	All	0.161	0.409	.001	33	view →
LGG	DFS	Tertile	All	0.773	0.892	<.001	33	view →
STAD	OS	Median	All	0.355	0.703	.008	25	view →
HNSC	DFS	Tertile	IV	0.632	0.451	.007	17	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	15	view →
SCLC	DFS	Median	IV	0.137	0.559	.008	15	view →
PRAD	DFS	Tertile	All	0.962	0.872	.002	14	view →
READ	DFS	Median	All	0.429	0.690	.021	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ADAMTS9–UVM (DFS)

Open the UVM breakdown →