ADAMTS8

Across TCGA cell cohorts, ADAMTS8 mutation is significantly associated with the RNA expression of many other genes, with 204 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTS8-associated genes across cancer lineages are OR2L3, PNLIPRP1, and MBD3L4. Each is linked with ADAMTS8 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTS8-to-partner and partner-to-ADAMTS8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2L3 grouped by ADAMTS8-low versus ADAMTS8-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS8→partner) and Y-score (partner→ADAMTS8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	OR2L3 →	+0.026	+3.954	.002	.001	3	2
LUNG_NSCLC_LUAD	PNLIPRP1 →	+0.021	+3.362	<.001	.007	3	2
LUNG_NSCLC_LUAD	MBD3L4 →	+0.011	+4.266	<.001	.004	3	2
BLOOD_Leukemia	CFHR2 →	+0.296	+4.539	<.001	.007	3	2
KIDNEY	CASP5 →	+0.194	+3.716	<.001	.005	3	1
KIDNEY	NUP210L →	+0.031	+3.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 204 associations by consensus.

OR2L3 by ADAMTS8 expression — KIDNEY

Explore this box plot interactively →