ADAMTS8

Across TCGA pan-cancer cohorts, ADAMTS8 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ADAMTS8’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ADAMTS8 RNA is repressed in tumor relative to normal tissue. In most cancer types ADAMTS8 is over-expressed in tumor, although a few such as LUAD and BLCA show the opposite, repressed pattern.

LUAD, BLCA, and KICH are the cancer types where ADAMTS8 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAMTS8 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−4.433	<.001	11	view →
BLCA	Male	All	−3.129	<.001	11	view →
KICH	Female	III,IV	−2.013	<.001	11	view →
KIRC	Male	II,III,IV	−0.947	<.001	11	view →
LUSC	Female	II,III,IV	−4.867	<.001	9	view →
HNSC	Male	All	−0.534	<.001	8	view →
BRCA	Female	II,III,IV	−1.087	<.001	6	view →
COAD	Male	All	−1.166	<.001	5	view →
UCEC	All	III,IV	−1.547	.019	4	view →
KIRP	All	All	−0.669	<.001	4	view →
STAD	All	All	−0.903	.016	3	view →
READ	All	All	−1.671	.008	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ADAMTS8–LUAD

Open the LUAD breakdown →