ADAMTS19

Across TCGA cell cohorts, ADAMTS19 mutation is significantly associated with the RNA expression of many other genes, with 657 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAMTS19-associated genes across cancer lineages are C16orf90, CYP2C19, and USP17L11. Each is linked with ADAMTS19 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAMTS19-to-partner and partner-to-ADAMTS19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf90 grouped by ADAMTS19-low versus ADAMTS19-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS19→partner) and Y-score (partner→ADAMTS19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	C16orf90 →	+0.023	+5.087	<.001	.004	3	2
SOFT_TISSUE	CYP2C19 →	+0.047	+4.295	<.001	.002	3	2
SOFT_TISSUE	USP17L11 →	+0.146	+3.865	<.001	.006	3	2
LUNG_NSCLC_LUAD	R3HDML →	+0.110	+3.536	.002	.001	3	2
LUNG_SCLC	CST2 →	+0.032	+3.232	.001	.008	3	2
LUNG_SCLC	OR2J3 →	+0.029	+4.058	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 657 associations by consensus.

C16orf90 by ADAMTS19 expression — URINARY_TRACT

Explore this box plot interactively →