ADAMTS19

Across TCGA pan-cancer cohorts, ADAMTS19 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ADAMTS19 data layer compared with 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ADAMTS19 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ADAMTS19 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LGG show a favorable association.

UCEC, UVM, and LGG are the cancer types where ADAMTS19 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	0.910	0.790	.002	86	view →
UVM	DFS	Median	II,III,IV	0.415	0.707	<.001	49	view →
LGG	OS	Median	All	0.880	0.740	<.001	39	view →
LUSC	DFS	Quartile	III,IV	0.479	0.799	.001	37	view →
PAAD	OS	Median	All	0.622	0.392	.004	27	view →
ESCA	OS	Tertile	II,III,IV	0.652	0.327	.005	23	view →
ACC	OS	Quartile	All	0.266	0.812	.002	22	view →
STAD	DFS	Tertile	All	0.443	0.597	.017	21	view →
COAD	OS	Quartile	All	0.421	0.746	.010	16	view →
THCA	OS	Tertile	IV	0.817	1.000	.007	15	view →
MESO	OS	Quartile	All	0.440	0.195	.016	15	view →
PRAD	DFS	Quartile	All	0.941	0.821	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ADAMTS19–UCEC (OS)

Open the UCEC breakdown →