ADAMTS14

Across TCGA patient cohorts, ADAMTS14 mutation is significantly associated with the RNA expression of many other genes, with 4,794 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS14-associated genes across cancer lineages are SHQ1P1, BRI3BP, and DCLRE1A. Each is linked with ADAMTS14 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADAMTS14-to-partner and partner-to-ADAMTS14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SHQ1P1 grouped by ADAMTS14-low versus ADAMTS14-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS14→partner) and Y-score (partner→ADAMTS14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SHQ1P1 →	+0.038	+1.869	<.001	.003	3	5
UCEC	BRI3BP →	+0.578	+2.332	<.001	<.001	3	4
COAD	DCLRE1A →	+0.450	+3.598	.007	.001	3	4
UCEC	TAF9 →	+0.615	+2.087	<.001	<.001	3	4
COAD	GEMIN2 →	+0.527	+3.210	.001	.009	3	4
UCEC	WDR76 →	+0.668	+1.699	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,794 associations by consensus.

SHQ1P1 by ADAMTS14 expression — LUAD

Explore this box plot interactively →