ADAMTS14

Across TCGA pan-cancer cohorts, ADAMTS14 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ADAMTS14’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ADAMTS14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ADAMTS14 is over-expressed in tumor.

HNSC, KIRC, and STAD are the cancer types where ADAMTS14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAMTS14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.240	<.001	12	view →
KIRC	Male	IV	+0.916	<.001	11	view →
STAD	Male	II,III,IV	+2.380	<.001	10	view →
THCA	All	III,IV	+1.698	<.001	10	view →
COAD	Male	II,III,IV	+1.116	<.001	10	view →
LUAD	Female	II,III,IV	+1.850	<.001	9	view →
LUSC	All	II,III,IV	+1.392	<.001	8	view →
BLCA	Female	All	+1.008	.003	7	view →
KIRP	All	III,IV	+0.766	<.001	7	view →
BRCA	All	III,IV	+1.955	<.001	6	view →
UCEC	All	All	+0.874	<.001	6	view →
READ	All	All	+1.707	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ADAMTS14–HNSC

Open the HNSC breakdown →