ADAMTS14

Across TCGA pan-cancer cohorts, ADAMTS14 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated ADAMTS14 data layer compared with 9 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ADAMTS14 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ADAMTS14 expression acts as an unfavorable survival marker, although some lineages such as SKCM and SCLC show a favorable association.

KIRC, UVM, and ACC are the cancer types where ADAMTS14 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.533	0.716	<.001	186	view →
UVM	DFS	Median	All	0.388	0.803	<.001	120	view →
ACC	DFS	Quartile	All	0.290	0.778	<.001	98	view →
MESO	OS	Median	All	0.429	0.662	<.001	83	view →
LIHC	OS	Quartile	III,IV	0.157	0.701	<.001	59	view →
KIRP	DFS	Median	All	0.490	0.973	<.001	57	view →
LGG	DFS	Median	All	0.651	0.820	<.001	54	view →
SKCM	OS	Tertile	III,IV	0.927	0.653	.001	39	view →
COAD	OS	Median	All	0.391	0.638	.007	36	view →
BLCA	OS	Quartile	II,III,IV	0.342	0.603	.008	19	view →
CESC	DFS	Median	All	0.666	0.808	.002	18	view →
GBM	DFS	Median	All	0.160	0.322	<.001	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

ADAMTS14–KIRC (OS)

Open the KIRC breakdown →