ADAMTS10

Across TCGA patient cohorts, ADAMTS10 mutation is significantly associated with the RNA expression of many other genes, with 3,727 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAMTS10-associated genes across cancer lineages are MRPS30, TIMM21, and SENP3-EIF4A1. Each is linked with ADAMTS10 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADAMTS10-to-partner and partner-to-ADAMTS10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPS30 grouped by ADAMTS10-low versus ADAMTS10-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAMTS10→partner) and Y-score (partner→ADAMTS10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MRPS30 →	+0.353	+1.410	<.001	<.001	3	4
STAD	TIMM21 →	+0.390	+2.857	.005	.001	3	4
STAD	SENP3-EIF4A1 →	+0.169	+1.991	<.001	.007	3	4
STAD	DNAAF4 →	+0.303	+2.355	.008	.003	3	3
LIHC	GPR32 →	+0.034	+4.564	<.001	.006	3	3
COAD	GRPEL2 →	+0.557	+3.348	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,727 associations by consensus.

MRPS30 by ADAMTS10 expression — SKCM

Explore this box plot interactively →