ADAMTS10

Across TCGA pan-cancer cohorts, ADAMTS10 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ADAMTS10 data layer compared with 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ADAMTS10 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ADAMTS10 expression acts as an unfavorable survival marker, although some lineages such as HNSC and DLBC show a favorable association.

HNSC, OV, and LUSC are the cancer types where ADAMTS10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	III,IV	0.405	0.186	<.001	112	view →
OV	DFS	Median	II,III,IV	0.135	0.182	.008	46	view →
LUSC	DFS	Median	II,III,IV	0.518	0.697	<.001	41	view →
CESC	DFS	Median	All	0.771	0.870	.008	26	view →
KIRC	DFS	Quartile	All	0.502	0.682	.005	21	view →
DLBC	OS	Tertile	II,III,IV	1.000	0.329	.008	21	view →
LGG	DFS	Quartile	All	0.302	0.477	.002	19	view →
LIHC	DFS	Median	III,IV	0.453	0.267	.004	19	view →
UVM	DFS	Quartile	III,IV	0.216	1.000	.006	15	view →
UCS	OS	Tertile	IV	0.323	0.756	.024	12	view →
STAD	DFS	Quartile	All	0.475	0.641	.011	12	view →
SKCM	DFS	Quartile	IV	0.396	0.041	.024	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ADAMTS10–HNSC (DFS)

Open the HNSC breakdown →