ADAM7

Across TCGA cell cohorts, ADAM7 RNA expression is significantly associated with the mutation status of many other genes, with 738 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAM7-associated genes across cancer lineages are PDE3A, WSCD1, and COPA. Each is linked with ADAM7 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM7-to-partner and partner-to-ADAM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDE3A grouped by ADAM7-low versus ADAM7-high in LARGE_INTESTINE.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM7→partner) and Y-score (partner→ADAM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDE3A →	+2.208	+0.002	.002	<.001	3	3
BLOOD_Leukemia	WSCD1 →	+2.922	+0.018	.009	<.001	3	3
LARGE_INTESTINE	COPA →	+2.667	+0.003	<.001	<.001	3	3
LARGE_INTESTINE	ZSWIM6 →	+2.667	+0.003	<.001	<.001	3	3
BLOOD_Myeloma	FAM135B →	+4.285	+0.204	.003	.003	3	2
KIDNEY	ABCA2 →	+3.652	+0.060	.006	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 738 associations by consensus.

PDE3A by ADAM7 expression — LARGE_INTESTINE

Explore this box plot interactively →