ADAM7

Across TCGA pan-cancer cohorts, ADAM7 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ADAM7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ADAM7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ADAM7 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, KIRP, and KICH are the cancer types where ADAM7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAM7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+0.030	.003	9	view →
KIRP	All	All	+1.147	.005	6	view →
KICH	All	All	−0.099	<.001	5	view →
LUSC	All	All	+0.018	.005	2	view →
THCA	Female	All	−0.006	.006	2	view →
LUAD	All	II,III,IV	+0.015	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ADAM7–HNSC

Open the HNSC breakdown →