ADAM7

Across TCGA cell cohorts, ADAM7 mutation is significantly associated with the RNA expression of many other genes, with 1,084 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAM7-associated genes across cancer lineages are ASB10, LILRA5, and PTCRA. Each is linked with ADAM7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM7-to-partner and partner-to-ADAM7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB10 grouped by ADAM7-low versus ADAM7-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM7→partner) and Y-score (partner→ADAM7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ASB10 →	+0.016	+5.285	<.001	.003	3	2
LUNG_NSCLC_LUAD	LILRA5 →	+0.025	+3.189	<.001	.007	3	2
OESOPHAGUS	PTCRA →	+0.413	+4.906	<.001	.006	3	1
LUNG_SCLC	OR2T6 →	+0.035	+5.029	<.001	.006	3	1
BLOOD_Leukemia	SERPINA4 →	+0.007	+2.922	<.001	.009	3	1
BLOOD_Leukemia	MS4A15 →	+0.099	+3.343	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,084 associations by consensus.

ASB10 by ADAM7 expression — STOMACH

Explore this box plot interactively →