ADAM22

Across TCGA patient cohorts, ADAM22 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM22-associated genes across cancer lineages are JNK_pT183_Y185, ASNS, and ERK2. Each is linked with ADAM22 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM22-to-partner and partner-to-ADAM22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by ADAM22-low versus ADAM22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM22→partner) and Y-score (partner→ADAM22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.092	-1.222	.049	.032	3	3
UCEC	ASNS →	+0.274	+1.289	.006	.021	3	3
UCEC	ERK2 →	+0.126	+1.137	.018	.037	3	2
UCEC	MEK1 →	+0.372	+2.662	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.267	+1.321	.003	.005	3	2
UCEC	PRAS40_pT246 →	+0.097	+1.247	.042	.041	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

JNK_pT183_Y185 by ADAM22 expression — UCEC

Explore this box plot interactively →