ADAM22

Across TCGA cell cohorts, ADAM22 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,423 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADAM22-associated GO terms across cancer lineages are Positive regulation of DNA repair, Regulation of DNA recombination, and Positive regulation of DNA recombination. Each is linked with ADAM22 in more than 13 cancer types. Because this analysis shows association rather than direction, both ADAM22-to-partner and partner-to-ADAM22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA repair grouped by ADAM22-low versus ADAM22-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM22→partner) and Y-score (partner→ADAM22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Positive regulation of DNA repair →	+0.076	+1.654	<.001	<.001	3	14
PANCREAS	Regulation of DNA recombination →	+0.066	+0.864	<.001	.007	3	14
STOMACH	Positive regulation of DNA recombination →	+0.105	+1.819	<.001	<.001	3	13
BONE	Regulation of body fluid levels →	-0.079	-1.227	<.001	<.001	3	13
OESOPHAGUS	Positive regulation of DNA metabolic process →	+0.061	+1.146	<.001	.003	2	14
STOMACH	Regulation of DNA repair →	+0.054	+1.887	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,423 associations by consensus.

Positive regulation of DNA repair by ADAM22 expression — OESOPHAGUS

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