ADAM22

Across TCGA cell cohorts, ADAM22 mutation is significantly associated with the RNA expression of many other genes, with 323 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADAM22-associated genes across cancer lineages are GP9, KRTAP21-2, and RESP18. Each is linked with ADAM22 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM22-to-partner and partner-to-ADAM22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GP9 grouped by ADAM22-low versus ADAM22-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM22→partner) and Y-score (partner→ADAM22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	GP9 →	+0.280	+3.058	<.001	.004	3	3
LUNG_SCLC	KRTAP21-2 →	+0.072	+3.169	<.001	.005	3	2
LUNG_NSCLC_LUAD	RESP18 →	+0.017	+3.947	.001	.004	3	2
LARGE_INTESTINE	KIF26A →	+1.073	+3.169	.001	.009	3	2
OESOPHAGUS	LILRA5 →	+0.042	+4.857	<.001	<.001	3	1
LUNG_SCLC	NAT2 →	+0.467	+3.584	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 323 associations by consensus.

GP9 by ADAM22 expression — LUNG_SCLC

Explore this box plot interactively →