ADAM21P1

Across TCGA patient cohorts, ADAM21P1 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADAM21P1-associated genes across cancer lineages are Ku80, p38-MAPK_pT180_Y182, and JNK_pT183_Y185. Each is linked with ADAM21P1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADAM21P1-to-partner and partner-to-ADAM21P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ADAM21P1-low versus ADAM21P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM21P1→partner) and Y-score (partner→ADAM21P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.170	+1.453	.038	.015	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.412	-1.723	.008	.007	3	2
UCEC	JNK_pT183_Y185 →	-0.151	-2.222	.009	.010	3	2
SKCM	JNK2 →	-0.141	-1.485	.028	.049	3	2
LUAD	Beclin →	+0.213	+2.824	.001	.034	3	1
UCEC	A-Raf_pS299 →	-0.084	-2.115	.041	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Ku80 by ADAM21P1 expression — UCEC

Explore this box plot interactively →