ADAM21P1

Across TCGA pan-cancer cohorts, ADAM21P1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ADAM21P1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ADAM21P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ADAM21P1 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where ADAM21P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADAM21P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	+0.057	.004	7	view →
KICH	All	All	−0.030	<.001	7	view →
LIHC	All	All	+0.015	<.001	6	view →
KIRC	All	II,III,IV	−0.026	<.001	5	view →
BRCA	All	All	+0.050	.021	4	view →
STAD	Female	All	+0.042	.020	3	view →
PRAD	All	All	+0.087	<.001	2	view →
LUAD	All	All	+0.052	.010	2	view →
UCEC	All	III,IV	+0.047	.046	2	view →
LUSC	All	All	+0.037	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ADAM21P1–HNSC

Open the HNSC breakdown →