ADAM18

Across TCGA cell cohorts, ADAM18 mutation is significantly associated with the RNA expression of many other genes, with 72 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ADAM18-associated genes across cancer lineages are DEFA5, RNASE9, and GML. Each is linked with ADAM18 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADAM18-to-partner and partner-to-ADAM18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFA5 grouped by ADAM18-low versus ADAM18-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADAM18→partner) and Y-score (partner→ADAM18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	DEFA5 →	+0.131	+4.584	.001	.001	3	2
BONE	RNASE9 →	+0.006	+5.169	<.001	.004	3	1
OESOPHAGUS	GML →	+0.026	+4.906	<.001	.006	3	1
OESOPHAGUS	GOLGA6L6 →	+0.016	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUSC	CCDC140 →	+0.083	+4.643	.001	.008	3	1
LUNG_NSCLC_LUSC	GALP →	+0.040	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 72 associations by consensus.

DEFA5 by ADAM18 expression — CNS

Explore this box plot interactively →